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KMID : 0043320090320030329
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Archives of Pharmacal Research
2009 Volume.32 No. 3 p.329 ~ p.334
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Lignan Constituents from Chloranthus japonicus Sieb.
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Lu Shao-Wa
Wang Qiu-hong
Yang Bing-You
Xia Yong-Gang
Kuang Hai-Xue
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Abstract
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A new coumarinolignan glucoside named yinxiancaoside C, along with five known benzofuran lignans, have been isolated from the whole plant of Chloranthus japonicus Sieb. The structures of compounds 1-6 were elucidated by chemical and spectroscopic methods including 1DNMR, 2D-NMR, ESI-MS and HR-ESI-MS. Five known benzofuran lignans were firstly discovered in the Chloranthaceae. In addition, the cytotoxic activity of the isolated compounds against human hepatoma (Hepg-2), ovarian carcinoma (OV420), and breast cancer (MCF-7) cells was investigated by MTT method.
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KEYWORD
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Chloranthaceae, Chloranthus japonicus Sieb., Coumarinolignan glucoside, Benzofuran lignans, Cytotoxicity
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